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BI 1291583, a selective cathepsin C (CatC) inhibitor, has shown dose-dependent CatC and NE suppression in phase I trials and demonstrated efficacy in the phase II AIRLEAF ® trial, significantly prolonging time to first exacerbation while maintaining a placebo-like safety profile, with further investigations ongoing in cystic fibrosis-related bronchiectasis and a planned phase III AIRTIVITY ® trial [77,78] https://shop.ipsy.com/_next/image?url=https%3A%2F%2Fproduct-images.prod.ipsy.com%2Fproduct_images%2Fresized_media%2FKOALIFEVitaminCLipTreatment_Swatch.jpeg&w=3840&q=75 Color:2S 6500mah 65C EC5 Ing_Collagen Bacteriostatic Water vs Sterile Saline (0.9% NaCl) | BAC Water Supply
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