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The xenobiotic adaptation in arthropods evolves through multiple mechanisms (Figure 1) 13 , 14 , including reduced penetration through the cuticle, behavioral avoidance 15 , 16 , microbiome-mediated detoxification 17 - 20 , enhanced metabolic detoxification 21 - 25 , enhanced sequestration or excretion 13 , 19 , 26 , 27 , and target site insensitivity 28 - 32
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One cluster analysis of 131 ME/CFS patients diagnosed according to the Fukuda criteria revealed that 34% of patients experienced sympathetic symptoms with dysautonomia (and were associated with more severe disease severity), 5% from sympathetic symptoms alone, 21% parasympathetic, and 40% struggled with sympathovagal balance (331)
