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For example, dopaminergic compensatory mechanisms are known to stimulate dopaminergic function in surviving dopaminergic neurons 71,72,73 , so they could also be increasing iron demands at striatal terminals and lead to upregulation of iron transport into the region
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Furthermore, SCFAs function as natural inhibitors of HDAC to epigenetically control gene transcription and chromatin acetylation related to inflammation, apoptosis, fatty acid oxidation, cell differentiation, and cell proliferation (May and den Hartigh, 2023)
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