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Key findings include: A 2004 study by Khavinson and colleagues showed that Epitalon enabled human fibroblasts to exceed the Hayflick limit and complete additional cell divisions — direct evidence of telomere-mediated lifespan extension in human cells.3 A 2025 independent study by Al-Dulaimi and colleagues in Biogerontology confirmed that Epitalon extends telomere length via telomerase upregulation in human cell lines — the first major independent replication outside Khavinson's laboratory.4 A 2003 animal study by Anisimov and colleagues showed Epitalon extended lifespan and reduced spontaneous tumor incidence in SHR mice.5 A 2025 retinal cell study found that Epitalon improved wound healing under high-glucose conditions, reduced reactive oxygen species, and improved antioxidant gene expression.6 Beyond telomeres, Epitalon modulates pineal gland function and melatonin synthesis — relevant to circadian regulation, sleep architecture, and the broader neuroendocrine decline associated with aging

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doi: 10.1002/ar.23690