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File:Glutathione-skeletal.svg - Wikipedia
In confirmation of this finding, Gross et al
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In general, the rate of synthesis, regeneration, and recycling of glutathione is determined by three key factors 2 : Cellular levels of cysteineโCysteine availability is the rate-limiting step in glutathione production, so not enough cysteine and de novo synthesis of glutathione will slow Enzyme glutamate cysteine ligase (GCL) activity, in part regulated by glutathione feedback inhibition Glutathione depletion due to high levels of oxidative stress, inflammation, or exposure to xenobioticsโin these situations, de novo synthesis is upregulated Of course, as an antioxidant, one of the most important roles of glutathione is shielding cells from reactive oxygen species and reactive nitrogen species, but thatโs not its only job