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Overview Every cell in the body constantly walks a tightrope between building new molecules and defending itself against damage, and the HMP shunt is one of the main tools that makes both possible

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Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]