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Skeletal muscle is not only a main component of the locomotor system, but functions also as an endocrine organ by secreting numerous bioactive substances (myokines), including inflammatory factors (IL-6, IL-8, IL-15), brain-derived neurotrophic factor (BDNF), fibroblast growth factor 21, irisin, and extracellular vesicles such as exosomes (Scisciola et al., 2021
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