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If one assumes that the primary function of ferrous iron involves catalyzing the Fenton reaction to reductively cleave hydrogen peroxides and lipid hydroperoxides, initiating and propagating LPO, then the iron data clearly contradicts and is incompatible with the previous hypothesis that peroxynitrite is a critical mediator of APAP toxicity
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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Lee S.L., Hsu J.Y., Chen T.C., Huang C.C., Wu T.Y., Chin T.Y
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