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In line with this, in vitro experiments with cultured cells have shown that (i) increased GSH levels are protective against MeHg-induced neurotoxicity [90,91] and (ii) GSH monoethyl ester (a GSH precursor) protected against MeHg-neurotoxicity in a manner dependent on MRP1-mediated efflux [92], highlighting the important role of this family of proteins ( multidrug resistance-associated proteins ) in exporting the MeHg-GSH complex from cells
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The cited literature covers 3T3-L1 adipocytes, diet-induced-obesity mouse models, genetic NNMT knockdown and a combined dietary-switch experiment with microbiome endpoints
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