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Arsenic trioxide APL Acute promyelocytic leukemia GSH Glutathione iAs III Arsenite SAM S-adenosylmethionine MMA III Monomethylarsonous acid MMA V Monomethylarsonic acid DMA III Dimethylarsinous acid DMA V Dimethylarsinic acid iAs V Arsenate TMAO V Trimethylarsine oxide AS3MT Arsenic (+3 oxidation state) methyltransferase As(GS) 3 Arsenic triglutathione MMA(GS) 2 Monomethylarsenic diglutathione DMA III (GS) Dimethylarsenic glutathione AQPs Aquaglyceroporins MRP Multidrug resistance proteins GST Glutathione S transferase GSTP1 Glutathione S-transferase π1 (RBCs) red blood cells Cys Cysteine GLUT4 Glucose transporter type 4 PDK-1 3-phosphoinositide-dependent kinase-I mTOR Mammalian target of rapamycin GSIS Glucose stimulated insulin secretion JNK Jun N-terminal kinases MAPK mitogen-activated protein kinases ROS Reactive oxygen species NOX Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzymes NO Nitric oxide GPCR G-protein coupled receptors HO-1 Heme oxygenase-1 MCP-1 Monocyte chemo-attractant protein NER Nucleotide excision repair XPA xeroderma pigmentosum group A protein MT metallothionein MTF1 Metal-activated transcription factor 1 ER Endoplasmic reticulum ATF4 Activating transcription factor 4 IRE1 Inositol-requiring enzyme 1 TRAF2 TNF-receptor-associated factor 2 PML Promyelocytic leukemia RARα Retinoic acid receptor alpha RBCC RING finger-B Box-Coiled Coil Footnotes FUNDING The authors wish to acknowledge the National Natural Science Foundation of China (No

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You can read more about NO and its effect on blood pressure in the Nitric Oxide and Blood flow article