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Oxidative stress inducers, such as oxidizing agents and electrophilic chemicals, cause KEAP1 oxidation, which inhibits NRF2 degradation by the KEAP1-Cullin3 ubiquitin ligase complex
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Size (mg):50mg
Thus, toxicant accumulated via larval feeding will persist in the animal through metamorphosis, effectively giving a pseudo-steady state internal dose (Figure 1)
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