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Iron in the body is essential for good health - but if too much builds up in the body, it can cause serious damage over time. The symptoms of iron overload are

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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]