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The Peptide Craze - Part 2: BPC-157, NAD⁺ and the Truth Behind the “Longevity Molecule” Hype

A landmark preclinical study published in Brain Research found that a single intranasal application of Semax (50 µg/kg) produced a 1.4-fold increase in BDNF protein levels, a 1.6-fold increase in TrkB phosphorylation, and a 3-fold increase in BDNF mRNA expression in the rat hippocampus

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They are all so-called “open ring (thiazole)” forms of thiamine and represent the most useful way of getting big doses of thiamine into the cell