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MOR and DOR activation in the DLS and DMS produce antagonist-irreversible LTD in young rats and mice as well as adult mice (Munoz et al., 2018, 2020)

Vitamin B complex deficiency

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It possible that current B12 deficiency treatment protocols for those with PA are poorly designed and that injections should be much more frequent but of a lower dosage (for example) to more effectively control symptoms