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This mitochondria calcium overload results in excessive mitochondrial Ca 2+ loading and Mt dysfunction with leaking and or loss that allows for the release of mtROS, Ca 2+ escape from mitochondria, and Ca 2+ overload, cytochrome C escape, and caspase signaling to result in apoptosis that associates with post-synaptic neurons with dendritic and/or axonal neurodegeneration (Figure 9) (Box 2) [96,97,98,99,100,101]

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