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Towards this goal, molecules that are associated with pathophysiological mechanisms (for example, pathophysiological mediators altered in the disease conditions) are promising candidates for such biomarkers
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Activation of mTORC1 leads to S6K1-mediated destabilization of insulin receptor substrate 1 (IRS1) and subsequent inhibition of IR and IGF-1R signaling [56], providing a negative feedback loop to downregulate AKT (Figure 1)
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