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GHK-Cu — Technical Lot Record · Lyos Labs

10.1007/s00204-023-03562-9 10.1007/s00204-023-03562-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Jomová K, Hudecova L, Lauro P, Simunkova M, Alwasel SH, Alhazza IM, Valko M (2019) A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3’,4’-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study

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Under hypoxic conditions, high expression of HIF-1α and HIF-2α can induce chondrocytes to secrete MMPs and a disintegrin and metalloproteinase with thrombospondin motifs-4, promote chondrocyte apoptosis, inhibit chondrocyte autophagy, and aggravate articular cartilage destruction (52, 53)