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Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)
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All of these changes, in turn, influence the anaerobic and pH environment of the intestinal lumen, potentially creating a niche for certain bacteria (e.g
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