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Activating NF-κB can regulate the ratio of Th17/Treg cells, and Th17 can secrete IL-17, which can induce the activation of NF-κB and TNF-α receptor-related factors, resulting in an increased transcription of genes encoding IL-6
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Endogenous RTAs were identified as protective in GPX4 deficient mice preceding the coining of ‘ferroptosis’ by Conrad’s group who showed that cell death could be abolished by alpha-tocopherol
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