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Under these conditions, the partially unfolded molecules display altered tertiary structures, while retaining or even increasing the secondary one, as it is the case of some natively unfolded proteins that temporarily acquire partially folded conformations [44,45], thus undergoing more or less heavy structural reorganization and self-assembly into fibrils [3,4]
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Ethics statement The animal study was reviewed and approved by the Ethics Committee School of Medicine, the University of Zagreb
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