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The first step of the pathway is stereospecific C-3 hydroxylation of Kme3 to 3-hydroxy-Kme3 (HTML) by N ε -trimethyllysine hydroxylase (TMLH), which is the only step that takes place in the mitochondria
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Some studies suggest that unbound GHK (without copper) may be just as effective in skin regeneration, sparking debates about whether copper binding is necessary
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