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Pediatric protocol (ages 3-12): Dose: 16 IU twice daily (32 IU total daily) Administration: Morning and evening Duration: 12 weeks in clinical trials Adult protocol: Dose: 24 IU twice daily (48 IU total daily) Administration: Morning and evening Duration: Variable, typically 4-12 weeks A 2025 meta-analysis found that high daily doses (48 IU) showed beneficial effects on social impairments, while lower doses showed no significant difference from placebo