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N5-N10-methylene tetrahydrofolate is particularly used in different reactions: it is used by (1) thymidylate synthase for formation of 2′-deoxythymidylate, (2) N5-N10-methylene tetrahydrofolate reductase for formation of N5-methyltetrahydrofolate, and (3) N5-N10-methylene tetrahydrofolate dehydrogenase to form N5-N10-methylene tetrahydrofolate [10, 23]
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[DOI] [PubMed] [Google Scholar] [126].Sanacora G, Treccani G, and Popoli M, Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
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