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Thus, supplementation with these compounds, in combination with advanced ART techniques such as IMSI, may offer a valuable strategy in the management of male infertility associated with poor sperm morphology and oxidative stress

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Combined, these observations suggest that the ability of PI3Kβ to initiate ROS production is independent of its kinase activity (Kulkani et al., 2011), but instead requires its ATP binding activity to stimulate phosphorylation of Akt and ERK downstream of FcγR activation