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Because in vitro studies had previously shown that 4-methylpyrazole is a competitive Cyp2E1 inhibitor binding to the substrate binding site of the enzyme [52,53], Yip and Heard [54] hypothesized a few years later that the positive outcome of the patient described in the case report may be related to a combined effect of NAC and fomepizole
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However, assessing the actual clinical effects of targeted agents for autophagy-related pathways on lung diseases is challenging
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