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When you’re in a state of nutritional ketosis with minimal systemic inflammation, extraordinarily high nutrient bioavailability from animal sources, and no plant anti-nutrients blocking absorption, your body’s actual requirements may be substantially lower than the population-wide recommendations designed for people eating inflammatory, grain-based diets

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In vitro studies suggested that genistein treatment of human keratinocytes and fibroblasts modulates glutathione content and reactive oxygen species release, endothelial/inducible (e/i)NOS dependent nitric oxide release, MMP expression, and mitochondria membrane potential through mechanisms involving p38 MAPK, AKT and ERK1/2 as downstream signaling associated with membrane ERs and GPER, as well as by increasing SOD activity and BCL2 expression in endothelial cells (Savoia et al., 2018