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Despite this fact, they have shown that the combination of PEA and polydatin neutralized oxidative stress and ROS formation by decreasing inducible nitric oxide synthase (iNOS) expression, poly-ADP ribose polymerase (PARP), and nitrotyrosine levels, but also by increasing the levels of the antioxidative enzyme manganese superoxide dismutase (MnSOD) [126]
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