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These modifications can change the conformation of proteins, resulting in dysfunction and the accumulation of misfolded proteins in the cytoplasm, which are implicated in cellular aging, apoptosis, and necrosis 89

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However, unlike PER, nuclear TIM levels in isolated PGs can be entrained to LD cycles in a cry -dependent manner, showing a presence of CRY activity in PG (Morioka et al., 2012)