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This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc⁻, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses
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Acta Haematol 123(2):117–120 [DOI] [PubMed] [Google Scholar] Riccioni G (2009) Carotenoids and cardiovascular disease
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