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Frontiers | Targeting L-arginine/NO/cGMP/KATP pathway by phytochemicals: therapeutic applications and clinical perspectives
For example, aromatic anticonvulsants are metabolized by CYP (cytochrome P450 - phase I of drug metabolism) into arene-oxide metabolites, normally detoxified in the conjugation pathways (phase II of drug metabolism) into inactive metabolites by epoxide hydrolase or glutathione transferase
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