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The effects of ROS may also be mediated by activating transcription factors, namely the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which releases cytokines that are proinflammatory, including interleukin-6 (IL-6) and tumor necrosis factor (TNF), and hastens the development of liver diseases (22–24)
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IFN-ɣ+NAC treatment led to the highest ER-tracker labeling in both 12Z and HESC cells, suggesting a synergistic impact on enhancing ER activity
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