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Increased potassium in the blood [5] Reduced amounts of the electrolytes sodium, calcium, and chloride in the blood [5] Increased serum muscle enzymes [5] Low glutathione peroxidase (GSH-PX) Low to normal serum vitamin E levels Darker than normal urine due to higher nitrogen excretion from the breakdown of muscle tissue Severe forms of NMD can be fatal due to cardiovascular arrhythmia , cardiovascular collapse, and fluid accumulation in the lungs (pulmonary edema)

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Acknowledgements The authors would like to thank Utragenyx for their medical writing support, provided by ClinSearch (Malakoff, France)