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The proportions of Asn, Asp, and isoAsp variants at residue 103 were determined by analyzing the chromatographic peak areas of distinct peptide variants (Figure 2a, peak 1–3)
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However, up to 50% of individuals carrying at least one ε4 allele do not develop AD, which suggests that there are other genetic and environmental factors at play ( Many other gene variants associated with AD encode proteins that regulate metabolism
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