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Moreover, epithelial cells and their tight junctions hinder the paracellular permeation of macromolecules, substantially reducing the efficiency of CNS drug delivery (Kel et al., 2022)
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After 20 days, the tumor tissue was stained with H & E, Ki67, and TUNEL to evaluate its anti-tumor effect, the major organs were stained with H & E to evaluate biological safety
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