glutathione peroxidase catalytic mechanism 4: a new player in neurodegeneration? #beautywhite4in1

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In fact, transgenic mice overexpressing NGF display elevated GSH concentrations in the plasma, brain, and liver ( Here, we document that a systemic reduction of GSH levels, up-regulates the transcription of L-cys/L-cys 2 and glutamate AA transporters and antioxidant genes in the striatum trough the TrkA/Akt pathway, which was mediated, at least in part, by peripheral NGF levels

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doi: 10.1097/MIB.0000000000000750 80 BisanzJEUpadhyayVTurnbaughJALyKTurnbaughPJ