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Unlike the brief action potentials in neurons and skeletal muscle fibers, cardiac myocytes exhibit a characteristic plateau phase in contractile cells (atria and ventricles) (Figure 1) and spontaneous, rhythmic firing in pacemaker cells (sinoatrial (SA) node [17,18]

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The angiopoietin-like proteins share structural, but not functional, similarity to angiopoietins which are members of the vascular endothelial growth factor family