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Bioavailability of testosterone micronized orally is low and highly variable, with estimates putting it at 3.56 +/-2.45%, with testosterone undecanoate having higher bioavailability at 6.83 +/- 3.32%, and methyltestosterone having the highest bioavailability at around 70%.15,16 It should be noted that this superior bioavailability of methyltestosterone due to avoiding first pass metabolism is associated with increased hepatotoxicity, whereas regular oral micronized testosterone and testosterone undecanoate salt, though they are significantly less bioavailable via the oral route, are not anticipated to present significant hepatotoxicity

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