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Under healthy conditions, intracellular glutamate concentration in erythrocytes is well below the K m (concentration of substrate required to reach half the maximum rate of reaction) for glutamate cysteine ligase (GCL), 19 one of the rate-limiting enzymes in glutathione synthesis 13 (Figure 1) so that increasing substrate (glutamate, L-cysteine) availability for GCL could theoretically increase the de novo synthesis of GSH
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In clinical studies, attending physicians prescribed NSAIDs at baseline, and patients were instructed to document their use for gout-related symptoms
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