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After discovering that the induction of IGF-1 production activates a pathway related to chemotherapy resistance (PIK3/AKT) and transportation to lactate from inside the cell outside, favoring tumor growth, researches have tried to develop strategies to overcome this issue, by simple starvation (72 h fasting prior to chemotherapy) or through starvation mimetics (nutraceuticals, for example), which are the compound that blocks this pathway or others related to, as the SGLT-2, reducing glucose uptake by cancer cells (283, 284)

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The mRNA expression of Gstm1 , but not other Gstm genes, dramatically decreased both at the basal level and after TNF-α stimulation in GSTM1 KD astrocytes (Supplementary Table S1)

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