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General BBB disruptions are also observed [5,19,40,108] through altered ZO-1, occluding, and ROS-mediated apoptosis induced by the p53/Bax/Bcl-2 signaling pathway [27,262] and enteric neuron loss [150] amid microbiota changes [151]
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doi: 10.1530/JOE-18-0596
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