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IUPAC-NIST Solubilities Database
Mechanically, due to the accumulated fumarates, C93 of GPX4 undergoes post-translational succination modification in FH −/- cells, and the reaction reduces the activity of GPX4 (Kerins et al., 2018)
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For instance, elevated circulating levels of fatty acid-binding protein 4 (FABP4) and glutathione peroxidase 3 (GPX3) were associated with declining insulin secretion, independent of insulin resistance [27]
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