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The main adverse events reported by male AAS users to SERMs (clomiphene and tamoxifen) were decreased libido and erectile dysfunction (24%), acne (21%), fatigue (19%), mood disorders (13%), visual disturbances (5%), arthralgia (4%), insomnia (4%), and hot flushes (2%)

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Animal model measurements All animal experiments were carried out according to the University of Ottawa animal care ethics and guidelines (protocol# HS2923)