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One study found that in INS1 ฮฒ-cells, high glucose decreased superoxide/mtROS production, which was attributed to pyruvate cycling activity from the malate-aspartate and citrate-isocitrate shuttle substrates (Plecita-Hlavata et al., 2020)
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rather, it suggests that maintaining healthy levels of this "master antioxidant" may be a key component of neurological resilience
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