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Calcitriols are a group of fat-soluble secosteroids that include vitamin D and its derivatives D 2 , D 3 , D 4 , and D 5 (Garcion et al., 3 is obtained through the skin during sun exposure and can be ingested (Eyles et al., 1997)

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Astrocytes derived from ALS post-mortem tissues trigger the death of neurons in co-cultures 237,238 , whereas transplantation of astrocytes derived from pluripotent stem cells obtained from patients with ALS into the spinal cord of mice resulted in the degeneration of motor neurons and motor deficits 239