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Pharmacology of Chloroquine and Hydroxychloroquine | Ento Key
Keywords: GPCR, GRK, second messenger-dependent protein kinase, PKC, PKA, desensitization, functional selectivity, MOPr GPCR desensitization: the classical model The desensitization of a G protein-coupled receptor (GPCR) response can be described as the loss of response subsequent to prolonged or repeated administration of an agonist (Hausdorff et al ., 1990)
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