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Preliminary animal studies show that exercise in high-fat diet mice resulted in reduced hepatic 4-HNE levels and upregulation of anti-apoptotic protein expression (Merry and Ristow, 2016)
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Consistent with existing literature that PTS cannot facilitate transport of phosphorylated sugars, the Δ glpD/ Δ golD/ Δ uhpT mutant relying on PTS was unable to grow hexose phosphates in vitro but retained ability to grow in the host cytosol
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