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Chronic administration of 7,8-DHF significantly improved motor deficits and enhanced lower neuronal survival in the transgenic ALS mouse model (Korkmaz et al., 2014) (Table 1)
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Notably, EGFR inhibitor alleviated cochlear oxidative stress damage, further confirming EGFR/p-ERK as a pivotal node in the ROS-GSDMD positive feedback loop
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