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Exposure of cells to 42 °C for 30 minutes or 50 μM H 2 O 2 for 20 minutes results only in a 50% increase in 4HNE concentrations above its basal levels, but this is accompanied by a transient activation of JNK that quickly subsides as the cells acquire the capacity to exclude 4HNE and bring concentrations to basal ‘physiologic’ levels

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