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Furthermore, the LCL NADPH/NADP + ratio was significantly diminished by MTHFD2 KO and restored by MTHFD2 R cDNA rescue (Figure 5G)
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MitoQ or mitoquinone is one of the most well characterized mitochondrial-targeted antioxidants and consists of oxidized CoQ10 moiety conjugated to TPP to facilitate accumulation within the mitochondria [102]
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