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33 In the fourth stage (colorectal cancer), the colon wall is thickened, intestinal narrowing occurs, and the patient may experience persistent abdominal pain, blood in the stool, and changes in bowel behavior, thus seriously affecting the patient’s life and health
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It inhibits the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), leading to prolonged monoaminergic neurotransmission
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